Is an Nvme SSD compatible with a SATA SSD slot on MB?

NVME drive uses pci-e signal, while SATA still uses SATA signal They are quite different Most ssd enclosures only support either one

slots, just that they are nvme OLED vs Traditional LED display Like charcoal vs propane or gas vs diesel, OLED vs LED continues to

m2 sata slot ASUSTOR FLASHSTOR 6 - 6x NVMe slots-image ASUSTOR FLASHSTOR 6

m24 slot wallet This video explains how to select which slot to use on a motherboard for the best storage